Amanda Miller

Dr. Amanda Miller earned a bachelor’s degree in Behavioral Biology from Johns Hopkins University and a Ph.D. in Neuroscience from Penn State College of Medicine. She completed predoctoral (Heart and Vascular Institute) and postdoctoral (Neural and Behavioral Sciences) fellowships at the Penn State College of Medicine.

Her research focuses on the autonomic nervous system and regulation of blood flow and blood pressure. Dr. Miller has expertise studying mechanisms of postural orthostatic tachycardia syndrome (POTS) and Ehlers-Danlos syndromes.

Select Peer-Reviewed Publications

Ross AJ, Medow MS, Rowe PC, Stewart JM. What is brain fog? An Evaluation of the symptom in postural tachycardia syndrome. Clin Auton Res. 2013 Dec;23(6):305-11. PMCID: PMC3896080.

Ross AJ, Ocon AJ, Medow MS, Stewart JM. A double-blind, placebo-controlled, crossover study of the vascular effects of midodrine in neuropathic compared with hyperadrenergic Postural Tachycardia Syndrome. Clin Sci (Lond). 2014 Feb;126(4):289-96. PMCID: PMC3896075.

Ross AJ, Yang H, Larson RA, Carter JR. Sleep Efficiency and Nocturnal Hemodynamic Dipping in Young, Normotensive Adults. Am J Physiol Regul Integr Comp Physiol. 2014 Oct 1;307(7):R888-92.  PMID:25031228.

Ross AJ, Gao Z, Heffernan M, Leuenberger UA, Sinoway LI, Muller MD. β-Adrenergic Receptor Blockade Impairs Coronary Exercise Hyperemia in Young Men but not Older Men. Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1497-503. PMCID:PMC4233304.

Ross AJ, Gao Z, Luck C, Blaha CA, Cauffman AE, Aziz F, Radtka JF, Proctor DN, Leuenberger UA, Sinoway LI, Muller MD. Coronary Exercise Hyperemia is Impaired in Patients with Peripheral Arterial Disease. Ann Vasc Surg. 2017 Jan 38: 260-267. PMCID: PMC5267559.

Miller AJ, Sauder C, Cauffman AE, Blaha CA, Leuenberger UA. Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia. Am J Physiol Regul Integr Comp Physiol. 2017 Feb 01; 312(2):R223-R228. PMCID: PMC5336567.

Wise S, Ross A, Brown A, Evans M, Jason L. An assessment of fatigue in patients with postural orthostatic tachycardia syndrome. J Health Psychol. 2017 May;22(6):733-742. PMID:26537521

Miller AJ, Luck JC, Muller MD, Kim D, Aziz F, Radtka JF, Leuenberger UA, Sinoway LI. Peripheral Revascularization attenuates the exercise pressor reflex and increases exercise hyperemia in peripheral arterial disease. J Appl Physiol (1985) 2018 Jul 1;125(1):58-63. PMCID: PMC6086975.

Miller AJ, Muller MD, Luck JC, Cui J, Sinoway LI. Age and Sex differences in sympathetic and hemodynamic responses to hypoxia and cold pressor test. Physiological Reports 2019 Jan;7(2):e13988.PMCID: PMC6339536.

Miller AJ, Raj SR. Pharmacotherapy for Postural Tachycardia Syndrome. Autonomic Neuroscience. 2018 Dec; 215 28-36. PMID: 29753556

Miller AJ, Arnold AC. The Renin-Angiotensin System in Cardiovascular Autonomic Control: Recent Developments and Clinical Implications. Clin Auton Res. 2019 Apr;29(2):231-243. PMCID: PMC6461499.

Miller AJ, Doherty, TA. Hop To It: The First Animal Model of Autoimmune Postural Orthostatic Tachycardia Syndrome. Journal of the American Heart Association. 2019 Oct;8(19):e014084. PMCID: PMC6806054.

Miller AJ, Schubart J, Sheehan T, Bascom R, Francomano CA. Arterial Elasticity in Ehlers-Danlos Syndromes. Genes 2020 Jan 4;11(1):55. PMCID: PMC7016526.

Miller AJ, Stiles LE, Sheehan T, Bascom R, Levy HP, Francomano CA, Arnold AC. Prevalence of Hypermobile Ehlers-Danlos Syndrome in Postural Orthostatic Tachycardia Syndrome. Autonomic Neuroscience 2020 Mar;224:102637. PMCID: PMC7282488. 

Miller AJ, Sheehan T, Bourne KM, Feeley M, Arnold AC. Attention and Executive Function are Impaired during Active Standing in Postural Tachycardia Syndrome. Autonomic Neuroscience. 2020 Sep;227:102692. PMCID: PMC7369241.

Miller AJ, Bingaman SS, Mehay D, Medina D, Arnold AC. Angiotensin-(1-7) Improve Integrated Cardiometabolic Function in Aged Mice. Int J Mol Sci 2020;21(14):5131. PMCID: PMC7403973.

Miller AJ, Bourne KM. Abdominal Compression as a Treatment for Postural Tachycardia Syndrome. Journal of the American Heart Association. 2020 Jul 21;9(14):e017610.

Autonomic Control in Aging. Peptides. 2021 Dec 29; 170733.  PMCID: PMC8923940

Miller AJ, Khan MS, Ejaz A, Molinger J, Goyal P, MacLeod DB, Swavely A, Wilson E, Pergola M, Tandri H, Frazier Mills C, Raj SR, Fudim M. Cerebral Blood Flow in Orthostatic Intolerance. J Am Heart Assoc. 2025;13:e036752. DOI: 10.1161/JAHA.124.036752. PMCID in progress

Presentations

Miller AJ, Wilson E, Blitshteyn S, Raj SR, Lee D, Fudim M. A novel in-ear wearable device correlates to autonomic symptoms better than heart rate does. The 35th International Symposium on the Autonomic Nervous System, November 2024. Platform and Poster Presentations.

Miller AJ, Lee D, Hsu J, Fudim M. Comparison of in-ear plethysmography to transcranial Doppler in orthostatic intolerance. The 35th International Symposium on the Autonomic Nervous System, November 2024. Poster Presentation.

• PHT 720: Neuroscience
• PHT 751: Evidence-Based Critical Inquiry
• PHT 752: Evidence in Practice
• MAS 170: Statistics for Health Professionals